Clinical validation of automatic phantom-less quantitative computed tomography for osteoporosis screening: fat region of interest comparison and multidevice validation
Yizhang Tong, Rong Gao, Chunxi Liu, Zhiling Ren, Wenjie Fu, Hongyan Yao, Ping Wang, Sheng Zhou · 2026
Read Clinical validation of automatic phantom-less quantitative computed tomography for osteoporosis screening: fat region of interest comparison and multidevice validation by Yizhang Tong, Rong Gao, Chunxi Liu, Zhiling Ren, Wenjie Fu, Hongyan Yao, Ping Wang, Sheng Zhou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13298776.txt.
Description
Bone density can be read from ordinary chest scans if the calibration holds up, and Yizhang Tong with colleagues validated an automated phantom-less system in a 2026 prospective study. Among 252 people having routine chest CT, the system measured spinal density at T11 to L1 without a physical reference phantom.
Against phantom-based measurement, results correlated strongly, with r = 0.867, and the system detected osteoporosis with an AUC of 0.962. Manually chosen visceral fat calibration beat the automatic subcutaneous fat choice for spotting early bone loss. Readings stayed consistent across five different scanners. The authors endorse the approach for opportunistic screening during scans done for other reasons.
Catalog record
| CREATOR | Yizhang Tong, Rong Gao, Chunxi Liu, Zhiling Ren, Wenjie Fu, Hongyan Yao, Ping Wang, Sheng Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60105 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |