Acute and Chronic High-Intensity Exercise Differentially Regulate the miRNA Biogenesis Pathway in Human Skeletal Muscle
Zeyu Wu, Eveline S. Menezes, Natalia de M. Lyra e Silva, Benjamin B. Arhen, Lucas P. R. Beaupre, Craig A. Simpson, Chris McGlory, Fernanda G. De Felice, Brendon J. Gurd · 2026
Read Acute and Chronic High-Intensity Exercise Differentially Regulate the miRNA Biogenesis Pathway in Human Skeletal Muscle by Zeyu Wu, Eveline S. Menezes, Natalia de M. Lyra e Silva, Benjamin B. Arhen, Lucas P. R. Beaupre, Craig A. Simpson, Chris McGlory, Fernanda G. De Felice, Brendon J. Gurd (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13298448.txt.
Description
Zeyu Wu and a large team examine whether intense exercise changes the machinery that builds microRNAs in human muscle, in a 2026 secondary analysis. Muscle biopsies came from two earlier studies: one single interval cycling bout, and six weeks of interval training against a control group. Gene messages and proteins for four biogenesis components were measured.
The single bout lowered one component's message, with a near-significant dip in another. Six weeks of training changed none of the measured proteins, and a representative muscle microRNA stayed flat at both early and mature stages. The authors highlight how complex microRNA control remains and ask for closer timing studies.
Catalog record
| CREATOR | Zeyu Wu, Eveline S. Menezes, Natalia de M. Lyra e Silva, Benjamin B. Arhen, Lucas P. R. Beaupre, Craig A. Simpson, Chris McGlory, Fernanda G. De Felice, Brendon J. Gurd |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |