A Coumarin-Based Probe for Sequential ON–OFF–ON Detection of Cu2+ and Biothiols: Naked-Eye Detection, Smartphone RGB Readout and In Vivo Imaging
Mingjie Wei, Linxin Zheng, Weilong Tian, Xingfeng Wang, Rong Liu, Lijuan Chen, Li Niu · 2026
Read A Coumarin-Based Probe for Sequential ON–OFF–ON Detection of Cu2+ and Biothiols: Naked-Eye Detection, Smartphone RGB Readout and In Vivo Imaging by Mingjie Wei, Linxin Zheng, Weilong Tian, Xingfeng Wang, Rong Liu, Lijuan Chen, Li Niu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13297486.txt.
Description
A glowing molecule that switches off for copper and back on for sulfur compounds is the subject of a 2026 chemistry paper by Mingjie Wei and co-authors. Their coumarin-based probe, named XDP, was built to follow copper ions and biothiols one after the other inside a single system.
Copper binding at the probe's imine site quenches its fluorescence, giving a linear response from 1 to 80 μM and a detection limit of 0.108 μM. Biothiols such as glutathione then pull the copper away and restore the glow, detectable from 1 to 30 μM. Copper also triggers a visible color change readable by eye or phone camera, and the probe imaged both events in living cells and zebrafish.
Catalog record
| CREATOR | Mingjie Wei, Linxin Zheng, Weilong Tian, Xingfeng Wang, Rong Liu, Lijuan Chen, Li Niu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38878 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |