Perfluorooctanoic Acid (PFOA) Alters the Structure of the Gut Microbial Community and Colonoid Transcription
LinShu Liu, Adrienne B. Narrowe, Jenni Firrman, Karley K. Mahalak, Venkateswari J. Chetty, Johanna M. S. Lemons, Aurélien Baudot, Pieter Van den Abbeele · 2026
Read Perfluorooctanoic Acid (PFOA) Alters the Structure of the Gut Microbial Community and Colonoid Transcription by LinShu Liu, Adrienne B. Narrowe, Jenni Firrman, Karley K. Mahalak, Venkateswari J. Chetty, Johanna M. S. Lemons, Aurélien Baudot, Pieter Van den Abbeele (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13297463.txt.
Description
LinShu Liu and colleagues test how PFOA, a long-lived industrial chemical, reshapes gut microbes and, through them, the gut lining, in a 2026 study. The chemical reaches the gut through food and lingers in the body. Stool from healthy adults was grown in a lab gut simulator with the chemical added at a level standing for long-term exposure.
The chemical broadly disrupted the microbe mix. One large group took over from two others, including microbes that make helpful short-chain fats. Liquid from the altered culture then acted on lab-grown gut tissue more strongly than either plain culture liquid or the chemical alone, tightening cell joints and shifting defence genes. Microbe changes may thus carry part of the chemical's harm.
Catalog record
| CREATOR | LinShu Liu, Adrienne B. Narrowe, Jenni Firrman, Karley K. Mahalak, Venkateswari J. Chetty, Johanna M. S. Lemons, Aurélien Baudot, Pieter Van den Abbeele |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |