Non-Psychoactive Cannabis Extract Disrupts Reinstatement and Reconsolidation in Cocaine-Induced Conditioned Place Preference in Mice
Fabián Leonardo Barreto, María Constanza Lozano, Yoshie Adriana Hata, Aura Rocio Hernández, Jorge A. Martínez-Ramírez · 2026
Read Non-Psychoactive Cannabis Extract Disrupts Reinstatement and Reconsolidation in Cocaine-Induced Conditioned Place Preference in Mice by Fabián Leonardo Barreto, María Constanza Lozano, Yoshie Adriana Hata, Aura Rocio Hernández, Jorge A. Martínez-Ramírez (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13297324.txt.
Description
Fabián Leonardo Barreto and colleagues test a cannabis extract that does not intoxicate against relapse-like behaviour in cocaine-trained mice, in a 2026 study. No approved drug treatment exists for cocaine use disorder, so memory-based routes draw interest. Mice learned to link one chamber with cocaine, then received the extract, rich in cannabidiol with little THC, around memory tests.
The extract weakened the return of cocaine seeking triggered both by a small cocaine dose and by stress. Given after memory recall sessions, it also seemed to disrupt the re-saving of the drug memory, with effects lasting at least two weeks. The extract alone caused neither liking nor dislike of a place. The work supports more study, in both sexes and other test setups.
Catalog record
| CREATOR | Fabián Leonardo Barreto, María Constanza Lozano, Yoshie Adriana Hata, Aura Rocio Hernández, Jorge A. Martínez-Ramírez |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |