Alginate Oligosaccharide Alleviates Severe Acute Pancreatitis in Mice via Suppression of Oxidative Stress, Inflammation and Modulation of Intestinal Epithelial Barrier Integrity
Xianglong Ou, Yi Dai, Xiangyue Hu, Yuan Liu, Shibin Yuan, Le Wang, Bangyuan Wu, Tingting Fang · 2026
Read Alginate Oligosaccharide Alleviates Severe Acute Pancreatitis in Mice via Suppression of Oxidative Stress, Inflammation and Modulation of Intestinal Epithelial Barrier Integrity by Xianglong Ou, Yi Dai, Xiangyue Hu, Yuan Liu, Shibin Yuan, Le Wang, Bangyuan Wu, Tingting Fang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13297282.txt.
Description
Xianglong Ou and colleagues pretreat, in 2026, mice with a seaweed-derived sugar for four weeks before triggering severe pancreas inflammation. This illness kills often and lacks good treatments, so the team check injury, gut barrier and microbes under the sugar's protection.
Treated mice showed lower digestive enzyme leaks, less tissue damage and muted inflammatory signals in pancreas and gut. A key inflammatory pathway quieted while an antioxidant axis woke, gut lining seals strengthened and fewer bacteria escaped to the pancreas. Gut microbes regained variety with helpful kinds enriched. The authors propose the sugar as nutrition-based support.
Catalog record
| CREATOR | Xianglong Ou, Yi Dai, Xiangyue Hu, Yuan Liu, Shibin Yuan, Le Wang, Bangyuan Wu, Tingting Fang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40147 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |