Clinical and Pathological Features That Predict High-Grade B-Cell Lymphomas (HGBCLs) with MYC and BCL2 or BCL6 Translocations (Double-Hit Lymphoma): A Systematic Review and Meta-Analysis
Ernest Lee, Wai Ying Katherine Wong, Han-Chieh Yang, Elizabeth J. Soilleux · 2026
Read Clinical and Pathological Features That Predict High-Grade B-Cell Lymphomas (HGBCLs) with MYC and BCL2 or BCL6 Translocations (Double-Hit Lymphoma): A Systematic Review and Meta-Analysis by Ernest Lee, Wai Ying Katherine Wong, Han-Chieh Yang, Elizabeth J. Soilleux (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13297255.txt.
Description
Ernest Lee and co-authors pool, in 2026, twenty-nine studies hunting bedside and lab clues that flag double-hit lymphoma, an aggressive B-cell cancer carrying two gene swaps. The confirming gene test is costly and scarce, so the team ask which features should trigger it.
Double-hit patients more often had advanced stage, higher risk scores, raised enzyme levels and a germinal-centre cell type. The two swap pairings differed too: one leaned to outside-node and brain spread with a non-germinal profile. Mixed methods and cut-offs across studies limited certainty. The authors offer the pattern as triage guidance.
Catalog record
| CREATOR | Ernest Lee, Wai Ying Katherine Wong, Han-Chieh Yang, Elizabeth J. Soilleux |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48872 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |