Exosomal MALAT1 from Rapid Electrical Stimulation-Treated Atrial Fibroblasts Activates Autophagy by Downregulating miR-204-5p and Upregulating LC3B
Su-Kiat Chua, Bao-Wei Wang, Ying-Ju Yu, Wei-Jen Fang, Chiu-Mei Lin, Cheng-Yen Chuang, Kou-Gi Shyu · 2026
Read Exosomal MALAT1 from Rapid Electrical Stimulation-Treated Atrial Fibroblasts Activates Autophagy by Downregulating miR-204-5p and Upregulating LC3B by Su-Kiat Chua, Bao-Wei Wang, Ying-Ju Yu, Wei-Jen Fang, Chiu-Mei Lin, Cheng-Yen Chuang, Kou-Gi Shyu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13297054.txt.
Description
Su-Kiat Chua and co-authors trace, in 2026, how rapid electrical pacing of human atrial fibroblasts switches on self-eating through a long RNA signal. Paced cells shed tiny packets rich in MALAT1, a regulatory RNA tied to atrial fibrillation scarring.
Reporter tests and gain-and-loss experiments confirm a chain: MALAT1 soaks up a small RNA, freeing a self-eating protein to rise and activate the process. Blocking any link in the chain damped the response. The authors name the axis a possible drug target for limiting structural damage in fibrillating atria and related rhythm care.
Catalog record
| CREATOR | Su-Kiat Chua, Bao-Wei Wang, Ying-Ju Yu, Wei-Jen Fang, Chiu-Mei Lin, Cheng-Yen Chuang, Kou-Gi Shyu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32748 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |