Growth of Escherichia coli in Minimal Media Supplemented with N6-Methylated but Not N6,N6-Dimethylated Purines Is Supported by Adenosine Deaminase Add
Jaunius Urbonavičius, Augusta Ivaškė, Daiva Tauraitė · 2026
Read Growth of Escherichia coli in Minimal Media Supplemented with N6-Methylated but Not N6,N6-Dimethylated Purines Is Supported by Adenosine Deaminase Add by Jaunius Urbonavičius, Augusta Ivaškė, Daiva Tauraitė (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13296781.txt.
Description
Jaunius Urbonavičius, Augusta Ivaškė, and Daiva Tauraitė work out how E. coli bacteria recycle methylated RNA building blocks in a 2026 study. Modified bases appear in RNA across life, but how bacteria strip the methyl groups and reuse the pieces was unknown. Mutant strains unable to make their own purines were fed modified bases in a minimal diet.
One methylated base supported growth of one mutant, showing the cells could convert it back to a usable form. The doubly methylated version supported no growth at all. Purified enzyme tests identified which deaminase performs the conversion, and which related enzyme cannot. The authors propose pathways that return these modified pieces to normal metabolism.
Catalog record
| CREATOR | Jaunius Urbonavičius, Augusta Ivaškė, Daiva Tauraitė |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |