Understanding and Overcoming Osteosarcoma Heterogeneity
Sukjoo Cho, Katherine Shelmidine, Jason T. Yustein · 2026
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Description
Sukjoo Cho, Katherine Shelmidine and Jason T. Yustein review, in 2026, why osteosarcoma, the main bone cancer of teenagers, varies so wildly within and between tumours. Treatment has barely changed in forty years, and this patchwork biology is blamed for stalled progress.
Causes span unstable genomes, broken tumour suppressors, extra copies of growth genes, inherited risks and a varied tumour neighbourhood, plus shape-shifting cells and chemical tags. Answers proposed include marker-guided risk sorting, better lab models and combined drugs hitting growth, immunity and metabolism. Maintenance therapy ideas are also weighed.
Catalog record
| CREATOR | Sukjoo Cho, Katherine Shelmidine, Jason T. Yustein |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52971 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |