Polydeoxyribonucleotide Mitigates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice Through the PKA/CREB/NF-κB Signaling Pathway
SeungHwan Lee, Lakkyong Hwang, Sang Hoon Kim, Sang Hoon Lee, Jin Hee Han, Jung Won Jeon, Hyeong Chan Shin, Il-Gyu Ko · 2026
Read Polydeoxyribonucleotide Mitigates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice Through the PKA/CREB/NF-κB Signaling Pathway by SeungHwan Lee, Lakkyong Hwang, Sang Hoon Kim, Sang Hoon Lee, Jin Hee Han, Jung Won Jeon, Hyeong Chan Shin, Il-Gyu Ko (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13296620.txt.
Description
SeungHwan Lee and colleagues test a DNA-derived compound against ulcerative colitis in mice, in a 2026 study. The compound, called PDRN, calms inflammation through a specific cell receptor. Colitis was triggered with a chemical in drinking water for seven days, and treated mice received daily injections.
Treated mice kept more body and colon weight, showed less tissue damage, and scored lower on a disease activity index. Inflammatory signals fell while a growth factor linked to tissue repair rose. Blocking the receptor with another drug erased the benefits, supporting the proposed pathway. The work is early animal evidence, pointing to signalling routes that future bowel-disease treatments might target.
Catalog record
| CREATOR | SeungHwan Lee, Lakkyong Hwang, Sang Hoon Kim, Sang Hoon Lee, Jin Hee Han, Jung Won Jeon, Hyeong Chan Shin, Il-Gyu Ko |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |