Role of Innate Lymphoid Cells in Chronic Rhinosinusitis: Insights from Tissue and Peripheral Blood Flow Cytometric Analysis
Rina Hoffmann, Franziska Rombach, Jens Grimm, Agmal Scherzad, Stephan Hackenberg, Pascal Ickrath · 2026
Read Role of Innate Lymphoid Cells in Chronic Rhinosinusitis: Insights from Tissue and Peripheral Blood Flow Cytometric Analysis by Rina Hoffmann, Franziska Rombach, Jens Grimm, Agmal Scherzad, Stephan Hackenberg, Pascal Ickrath (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13296213.txt.
Description
Rina Hoffmann and colleagues chart innate lymphoid cells in tissue and blood from people with chronic rhinosinusitis, in a 2026 study. These cells are strong makers of signaling proteins that steer local immune responses in the nose and sinuses. The team used flow cytometry to count cell kinds in polyp tissue, sinus tissue, and blood, sorting patients by whether polyps were present.
Natural killer cells in nasal tissue proved mixed and less mature than their blood kin. In polyps, killer cell counts ran lower, and type 2 lymphoid cells showed stronger marks of the type 2 program that feeds polyp growth. Counts of several subsets that answer to interleukin-18 ran low in polyps, hinting that this signal plays a small part there. The authors give killer cells a larger role in disease without polyps.
Catalog record
| CREATOR | Rina Hoffmann, Franziska Rombach, Jens Grimm, Agmal Scherzad, Stephan Hackenberg, Pascal Ickrath |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |