Expression of Phosphomimetic OSTM1-T328E/S329D Variant Partially Restores Bone Resorption Defect in LRRK1-Deficient Mice †
Anakha Udayakumar, Yian Chen, Haibo Zhao, Subburaman Mohan, Weirong Xing · 2026
Read Expression of Phosphomimetic OSTM1-T328E/S329D Variant Partially Restores Bone Resorption Defect in LRRK1-Deficient Mice † by Anakha Udayakumar, Yian Chen, Haibo Zhao, Subburaman Mohan, Weirong Xing (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13296195.txt.
Description
Anakha Udayakumar and co-authors test, in 2026, whether a chemical change on the protein OSTM1 explains how the kinase LRRK1 drives bone-eating cells. Mice lacking LRRK1 develop overly dense bone because their osteoclasts cannot break bone down, and tagging of OSTM1 fades in those cells.
A version of OSTM1 that mimics the tag partly restored bone breakdown in deficient cells, while a version blocking the tag did not. Mice built with the mimicking variant grew normally, and adding it to deficient mice boosted osteoclast activity and bone formation. The authors name OSTM1 tagging as a key link worth targeting.
Catalog record
| CREATOR | Anakha Udayakumar, Yian Chen, Haibo Zhao, Subburaman Mohan, Weirong Xing |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29252 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |