Kuwanon A from Morus alba L. Alleviates H2O2-Induced Oxidative Damage in HaCaT Keratinocytes by Inhibiting Ferroptosis and Enhancing Antioxidant Capacity
Yan Liu, Hening Fu, Junjie Ma, Youqing Wang, Zhaohua Shi, Yupeng Liu, Xianju Huang, Bingchen Han, Jun Li · 2026
Read Kuwanon A from Morus alba L. Alleviates H2O2-Induced Oxidative Damage in HaCaT Keratinocytes by Inhibiting Ferroptosis and Enhancing Antioxidant Capacity by Yan Liu, Hening Fu, Junjie Ma, Youqing Wang, Zhaohua Shi, Yupeng Liu, Xianju Huang, Bingchen Han, Jun Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13296179.txt.
Description
Yan Liu and eight colleagues isolate the protective ingredient in white mulberry root bark and trace how it shields skin cells from oxidative attack, in a 2026 study. The bark is a traditional antioxidant, but its active molecules were unmapped.
Twenty-two compounds were separated and identified, two of them new. The standout, Kuwanon A, saved peroxide-stressed skin cells by clearing reactive oxygen, restoring cell powerhouses, and boosting defense enzymes. The damage ran partly through ferroptosis, an iron-driven cell death, which the compound blocked by raising a sulfur-handling enzyme and its downstream protectors. Inflammation markers fell as well. The authors name Kuwanon A the bark's key defender.
Catalog record
| CREATOR | Yan Liu, Hening Fu, Junjie Ma, Youqing Wang, Zhaohua Shi, Yupeng Liu, Xianju Huang, Bingchen Han, Jun Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |