Gut Microbiota-Mediated Histidine Deficiency Drives Testicular Ferroptosis Induced by Bisphenol F Exposure
Bo-Yang Zhang, Yue-Qi Wang, Rui Yang, Yan Zhang, Dao-Zhen Jiang, Li-Hong Ji, Yi-Fei Mao, Bo Tang, Xue-Ming Zhang · 2026
Read Gut Microbiota-Mediated Histidine Deficiency Drives Testicular Ferroptosis Induced by Bisphenol F Exposure by Bo-Yang Zhang, Yue-Qi Wang, Rui Yang, Yan Zhang, Dao-Zhen Jiang, Li-Hong Ji, Yi-Fei Mao, Bo Tang, Xue-Ming Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13296130.txt.
Description
Bo-Yang Zhang and colleagues trace how bisphenol F, a stand-in for the curbed bisphenol A, harms mouse testes through the gut, in a 2026 study. Male mice got the compound daily for twenty-eight days at three doses. Their testes showed shrunken sperm-making tubes, hollow patches, and a weakened barrier that guards sperm, and the team dug into gut microbes and body chemistry for the chain behind it.
Gut microbe mixes shifted, helpful kinds thinned, and histidine handling in the gut was damped, leaving the testes short of histidine. Signs of ferroptosis, an iron-driven cell death, rose in the testes: hurt mitochondria, iron buildup, and fat damage. A histidine transporter mark also fell, though direct blocking of transport was not shown. The authors frame gut imbalance and histidine loss as the path from exposure to harm.
Catalog record
| CREATOR | Bo-Yang Zhang, Yue-Qi Wang, Rui Yang, Yan Zhang, Dao-Zhen Jiang, Li-Hong Ji, Yi-Fei Mao, Bo Tang, Xue-Ming Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |