Imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines as Inhibitors of Staphylococcus aureus Biofilm Formation
Domenico Schillaci, Fabiana Plescia, Fabio Scianò, Federica Parisi, Valentina Catania, Barbara Manachini, Serena Indelicato, Tania Ciaglia, Anna Di Dio, Stella Cascioferro · 2026
Read Imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines as Inhibitors of Staphylococcus aureus Biofilm Formation by Domenico Schillaci, Fabiana Plescia, Fabio Scianò, Federica Parisi, Valentina Catania, Barbara Manachini, Serena Indelicato, Tania Ciaglia, Anna Di Dio, Stella Cascioferro (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13296061.txt.
Description
Domenico Schillaci and colleagues build a library of new compounds meant to stop Staphylococcus aureus from forming biofilms, in a 2026 study. Biofilms are slimy cities of bacteria that shrug off standard drugs, and no anti-biofilm drug has yet reached the clinic. The team made twenty-one compounds that join two ring systems and tested them on two germs, in dishes and in wax moth larvae.
Five compounds blocked biofilm growth in the staph germ at low doses. The set was also checked for wiping out set biofilms in staph and in Pseudomonas aeruginosa. Two leaders went into the larvae for safety and anti-infective tests, and one, coded 9u, guarded the larvae well in the early stage of infection. The authors offer the family as a lead for biofilm care.
Catalog record
| CREATOR | Domenico Schillaci, Fabiana Plescia, Fabio Scianò, Federica Parisi, Valentina Catania, Barbara Manachini, Serena Indelicato, Tania Ciaglia, Anna Di Dio, Stella Cascioferro |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |