Depressive symptoms in chronic kidney disease: the hidden role of uremic toxins
Hélène Levassort, Sophie Liabeuf, Julie Boucquemont, Gaye Hafez, Solene M Laville, Celine Lange, Luc Frimat, Christian Combe, Denis Fouque, Maurice Laville, Christian Jacquelinet, Yves-Edouard Herpe, Lucile Montalescot, Islam Amine Larabi, Natalia Alencar de Pinho, Ziad A Massy, Jean-Claude Alvarez, Marion Pépin, on behalf of CKD-REIN · 2026
Read Depressive symptoms in chronic kidney disease: the hidden role of uremic toxins by Hélène Levassort, Sophie Liabeuf, Julie Boucquemont, Gaye Hafez, Solene M Laville, Celine Lange, Luc Frimat, Christian Combe, Denis Fouque, Maurice Laville, Christian Jacquelinet, Yves-Edouard Herpe, Lucile Montalescot, Islam Amine Larabi, Natalia Alencar de Pinho, Ziad A Massy, Jean-Claude Alvarez, Marion Pépin, on behalf of CKD-REIN (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13295914.txt.
Description
Hélène Levassort and colleagues follow, in 2026, whether waste toxins that build up in kidney disease track with worsening mood. Depression is common in this group, and such toxins may fuel brain inflammation, but the link had not been tested over time.
Within a large French cohort, 2,165 adults not on dialysis were followed for about four years with repeated mood scores and blood toxin measures. One toxin, phenylacetylglutamine, was tied to mood scores creeping upward over time, while two others linked to higher average scores. The authors ask whether lowering toxins could ease symptoms.
Catalog record
| CREATOR | Hélène Levassort, Sophie Liabeuf, Julie Boucquemont, Gaye Hafez, Solene M Laville, Celine Lange, Luc Frimat, Christian Combe, Denis Fouque, Maurice Laville, Christian Jacquelinet, Yves-Edouard Herpe, Lucile Montalescot, Islam Amine Larabi, Natalia Alencar de Pinho, Ziad A Massy, Jean-Claude Alvarez, Marion Pépin, on behalf of CKD-REIN |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48701 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |