A Biomimetic Amelogenin–Fibronectin Fusion Protein with Dual Cell-Adhesive and Osteoinductive Functions for Alveolar Bone Defect Repair
Mengsong Zheng, Xinyi Jiang, Minghua Lei, Bin Liang, Xiaoshuang Ye, Lining Xie, Peirong Zhang, Yili Li, An Hong, Zhijian Su, Xiaojia Chen · 2026
Read A Biomimetic Amelogenin–Fibronectin Fusion Protein with Dual Cell-Adhesive and Osteoinductive Functions for Alveolar Bone Defect Repair by Mengsong Zheng, Xinyi Jiang, Minghua Lei, Bin Liang, Xiaoshuang Ye, Lining Xie, Peirong Zhang, Yili Li, An Hong, Zhijian Su, Xiaojia Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13295594.txt.
Description
Mengsong Zheng and co-authors fuse two natural proteins into one that both grips cells and grows bone, in a 2026 regenerative study. Periodontitis rots the bone socketing teeth, and current materials rarely deliver adhesion and bone-building signals together. Amelogenin, a tooth-development protein, encourages mineralized tissue but sticks cells poorly. Fibronectin carries a famous three-letter grip motif, RGD. The team stitched amelogenin's conserved ends to that motif, creating a fusion named rtAmR.
Stem cells from tooth roots clung to the fusion and spread out at roughly double the rate seen with plain amelogenin. Bone-forming performance matched or beat the natural protein on enzyme activity, collagen output, and mineral nodule formation. In rat jaw defects the fusion rebuilt more bone than either parent protein, without drawing extra inflammatory cells. The authors propose rtAmR as a two-in-one scaffold for periodontal repair.
Catalog record
| CREATOR | Mengsong Zheng, Xinyi Jiang, Minghua Lei, Bin Liang, Xiaoshuang Ye, Lining Xie, Peirong Zhang, Yili Li, An Hong, Zhijian Su, Xiaojia Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |