Metformin as a Metabolic Reprogramming Interface in Host–Pathogen and Bone Microenvironment Crosstalk: A Dual-Target Strategy Against Antimicrobial Resistance and Osteoporotic Bone Loss
Shakta Mani Satyam, Ebrahim Safaii, Ilmia Shameer, Rashmi Kumari, Sainath Prabhakar, Mohamed Talat Zaky Mahmoud Eltrabishi, Mohamed El-Tanani, Abdul Rehman, Mohamed Tarek Mohamed Wageh Mohamed Abdelfattah · 2026
Read Metformin as a Metabolic Reprogramming Interface in Host–Pathogen and Bone Microenvironment Crosstalk: A Dual-Target Strategy Against Antimicrobial Resistance and Osteoporotic Bone Loss by Shakta Mani Satyam, Ebrahim Safaii, Ilmia Shameer, Rashmi Kumari, Sainath Prabhakar, Mohamed Talat Zaky Mahmoud Eltrabishi, Mohamed El-Tanani, Abdul Rehman, Mohamed Tarek Mohamed Wageh Mohamed Abdelfattah (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13295426.txt.
Description
Shakta Mani Satyam and colleagues propose a big-picture framework linking three problems usually studied apart: stubborn infections, immune dysfunction, and thinning bones, in a 2026 review. Their organizing idea casts metabolism as a shared control panel, and metformin, the familiar diabetes drug, as a hand on its dials. Metformin touches energy production in mitochondria, a master fuel sensor called AMPK, oxidative balance, and cellular recycling, all pathways implicated in both microbial persistence and bone turnover.
The authors are careful about the evidence ladder. Some mechanisms are experimentally solid, others are context-dependent hints from cell and animal work, and the combined infection-plus-bone benefit has never been tested in a proper prospective trial. Early findings suggest metformin can cramp microbes, cool excessive inflammation, and nudge bone remodeling, but each effect depends on setting. The framework is offered as a scaffold for testable hypotheses, not a proven model.
Catalog record
| CREATOR | Shakta Mani Satyam, Ebrahim Safaii, Ilmia Shameer, Rashmi Kumari, Sainath Prabhakar, Mohamed Talat Zaky Mahmoud Eltrabishi, Mohamed El-Tanani, Abdul Rehman, Mohamed Tarek Mohamed Wageh Mohamed Abdelfattah |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |