Aminochrome-Induced Disruption of Autophagosome-Lysosome Fusion: Implications for Protein Aggregation in Parkinson’s Disease
Andrea Briceño, Cipriano Núñez, Karina Cortés, Patricia Pallacán, Nicole Salinas, Carola Millán, Juan F. Vivanco, Nelson Caro, Juan Segura-Aguilar, Irmgard B. Paris · 2026
Read Aminochrome-Induced Disruption of Autophagosome-Lysosome Fusion: Implications for Protein Aggregation in Parkinson’s Disease by Andrea Briceño, Cipriano Núñez, Karina Cortés, Patricia Pallacán, Nicole Salinas, Carola Millán, Juan F. Vivanco, Nelson Caro, Juan Segura-Aguilar, Irmgard B. Paris (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13295424.txt.
Description
Andrea Briceño and colleagues study a brain toxin linked to Parkinson's disease in a 2026 laboratory article. Aminochrome forms inside dopamine neurons and is suspected in their loss. Its effects on the cell's waste clearing system, beyond known stress and skeleton damage, were poorly mapped.
In neuron-like cells, the toxin delayed the meeting of waste sacs with the digestive sacs that should clear them. Protein clumps marked by vimentin and ubiquitin piled up near and even inside the nucleus. Boosting the clearing process partly saved cells from death. The authors point to skeleton steadying and waste system support as joint treatment directions.
Catalog record
| CREATOR | Andrea Briceño, Cipriano Núñez, Karina Cortés, Patricia Pallacán, Nicole Salinas, Carola Millán, Juan F. Vivanco, Nelson Caro, Juan Segura-Aguilar, Irmgard B. Paris |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39901 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |