A Brain-Targeted Organophosphorus Hydrolase Fusion Protein Mediated by Angiopep-2 Neutralizes Central Organophosphates and Alleviates Neurotoxicity
Yanwei Xie, Yanan Zhai, Jiaxuan Shang, Ming Ma, Dan Wang, Shengye Xu, Yuhua Ran, Zhiping Li, Xiang Gao, Jing Gao · 2026
Read A Brain-Targeted Organophosphorus Hydrolase Fusion Protein Mediated by Angiopep-2 Neutralizes Central Organophosphates and Alleviates Neurotoxicity by Yanwei Xie, Yanan Zhai, Jiaxuan Shang, Ming Ma, Dan Wang, Shengye Xu, Yuhua Ran, Zhiping Li, Xiang Gao, Jing Gao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13295160.txt.
Description
Yanwei Xie and co-authors build a brain-seeking antidote for organophosphate poisoning in a 2026 study. These chemicals overstimulate nerves and can kill, while current care cannot clear them from the brain itself. An enzyme that destroys them exists but cannot cross the blood-brain barrier unaided.
The team fused a strong enzyme variant to Angiopep-2, a carrier that ferries cargo across that barrier through a known receptor. Imaging and effect studies in animals confirmed the fusion reached the brain, cleared poison lodged there, and eased nerve toxicity. The approach could improve outlooks for patients with brain-centred poisoning damage.
Catalog record
| CREATOR | Yanwei Xie, Yanan Zhai, Jiaxuan Shang, Ming Ma, Dan Wang, Shengye Xu, Yuhua Ran, Zhiping Li, Xiang Gao, Jing Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60806 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |