Self-synergizing mutual prodrug liposomes for targeted cancer therapy via redox-amplified Pin1 inhibition
Nuri Kim, Ilseob Kim, Hanui Jo, Nanhee Song, Sangmin Jo, Suyeon Lee, Hoechang Kim, Changjin Lim, Dongwon Lee · 2026
Read Self-synergizing mutual prodrug liposomes for targeted cancer therapy via redox-amplified Pin1 inhibition by Nuri Kim, Ilseob Kim, Hanui Jo, Nanhee Song, Sangmin Jo, Suyeon Lee, Hoechang Kim, Changjin Lim, Dongwon Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13295116.txt.
Description
Nuri Kim and colleagues build a self-boosting drug pair inside fat bubbles for cancer treatment in a 2026 study. Drug combinations often fail because the partners travel differently and arrive out of step. Their linked prodrug joins retinoic acid with a partner that drains a key cell protector, raising oxidative stress together.
The joined molecule forms cholesterol-free bubbles that gain a coating for longer circulation and tumour gathering. Inside tumour cells, an enzyme cut releases both partners at once, deepening stress and suppressing a cancer-linked protein called Pin1. Treated cells died more readily, and mouse tumours shrank strongly with little body-wide harm.
Catalog record
| CREATOR | Nuri Kim, Ilseob Kim, Hanui Jo, Nanhee Song, Sangmin Jo, Suyeon Lee, Hoechang Kim, Changjin Lim, Dongwon Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81387 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |