GRP78 in human diseases: From molecular chaperone to therapeutic target
Yang Li, Dan Mu, Jiajie Feng, Zhijia Li, Lan Zhang, Lei Wang · 2026
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Description
Yang Li and co-authors review a workhorse cell protein that moonlights across a surprising range of diseases, in a 2026 survey of GRP78. Also called BiP, the protein lives mainly in the endoplasmic reticulum, the cell's folding workshop, where it keeps new proteins folding correctly and manages the stress response when folding fails. Chemical tweaks such as phosphorylation tune its activity, and under stress it can relocate to the cell surface or nucleus for other jobs.
Misbehavior of GRP78 shows up in cancer, brain degeneration, infections, heart and blood vessel disease, inflammation, and metabolic disorders, sometimes helping and sometimes harming depending on tissue and stage. The review catalogs attempts to drug it, from small molecules to antibodies and gene-based tools, noting strong preclinical promise but weak specificity and slow progress to the clinic. Sharper tools and precision strategies, the authors argue, decide whether the target pays off.
Catalog record
| CREATOR | Yang Li, Dan Mu, Jiajie Feng, Zhijia Li, Lan Zhang, Lei Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 167 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |