Development of a Regioselective Synthetic Strategy and Cytotoxicity Examination of Alkoxy-Substituted Phenazine Derivatives That Disrupt G‑Quadruplex Structure
Paweł Ręka, Jakub Glac, Agata Głuszyńska, Jarosław Grolik, Magdalena Obłoza, Katarzyna Ostrowska · 2026
Read Development of a Regioselective Synthetic Strategy and Cytotoxicity Examination of Alkoxy-Substituted Phenazine Derivatives That Disrupt G‑Quadruplex Structure by Paweł Ręka, Jakub Glac, Agata Głuszyńska, Jarosław Grolik, Magdalena Obłoza, Katarzyna Ostrowska (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13294954.txt.
Description
Paweł Ręka and colleagues extend a selective recipe for building phenazine dyes and test the results on cancer cells, in a 2026 study. Phenazines are ring systems found in bacterial pigments, with a long record of killing microbes and tumors. The team's method places up to four unlike groups at chosen spots while forming only the wanted isomer, widening one branch of the family.
New compounds joined older kin in tests on mouse mammary cancer cells and human colon cancer cells. Three stood out with strong force in both lines. Tests on normal mouse mammary cells gave a best safety margin near two, which is modest. Chosen members were then checked against a folded DNA stretch from a cancer gene switch, and each one tested loosened that fold.
Catalog record
| CREATOR | Paweł Ręka, Jakub Glac, Agata Głuszyńska, Jarosław Grolik, Magdalena Obłoza, Katarzyna Ostrowska |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |