Structural basis of nucleosome remodeling by Cockayne syndrome B homologue Komagataella phaffii Rad26
Yutaro Fukushima, Chiaki Kinoshita, Lumi Negishi, Tomoya Kujirai, Yuki Kobayashi, Mitsuo Ogasawara, Haruhiko Ehara, Shun-ichi Sekine, Wataru Kagawa, Hitoshi Kurumizaka, Yoshimasa Takizawa · 2026
Read Structural basis of nucleosome remodeling by Cockayne syndrome B homologue Komagataella phaffii Rad26 by Yutaro Fukushima, Chiaki Kinoshita, Lumi Negishi, Tomoya Kujirai, Yuki Kobayashi, Mitsuo Ogasawara, Haruhiko Ehara, Shun-ichi Sekine, Wataru Kagawa, Hitoshi Kurumizaka, Yoshimasa Takizawa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13294370.txt.
Description
Yutaro Fukushima and a large team solve the structure of a DNA repair remodeler bound to a nucleosome in a 2026 cryo-microscopy study. Yeast Rad26, kin to human Cockayne syndrome protein B, helps restart copying after damage and shuffles nucleosomes. Frozen snapshots show where the machine grips the DNA spool during transcription-coupled repair.
Rad26 clamps near the spool entry point with its two motor lobes flipped versus other remodelers like Snf2 and Ino80. A lysine-arginine loop proved required for grip and shuffling in mutation and binding tests. The protein's own loose head normally brakes the motor through long-range contacts, released by two leucine changes. Shape explains repair choreography.
Catalog record
| CREATOR | Yutaro Fukushima, Chiaki Kinoshita, Lumi Negishi, Tomoya Kujirai, Yuki Kobayashi, Mitsuo Ogasawara, Haruhiko Ehara, Shun-ichi Sekine, Wataru Kagawa, Hitoshi Kurumizaka, Yoshimasa Takizawa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54394 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |