Detection of drug-induced acute respiratory distress syndrome risk signals in FAERS: a real-world pharmacovigilance study
Yunhan Zhao, Feiyang Zhao, Haoxiang Hu, Jianghai He, Yiting Ni, Pingping Jin, Xiao Wang, Zheru Jin, Yiren Hu · 2026
Read Detection of drug-induced acute respiratory distress syndrome risk signals in FAERS: a real-world pharmacovigilance study by Yunhan Zhao, Feiyang Zhao, Haoxiang Hu, Jianghai He, Yiting Ni, Pingping Jin, Xiao Wang, Zheru Jin, Yiren Hu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13294336.txt.
Description
Yunhan Zhao and coauthors mine United States adverse event reports for drugs that may trigger acute respiratory distress syndrome in a 2026 pharmacovigilance study. Case reports hinted at the danger, but broad real-world checks were missing. Reports were cleaned, deduplicated, and run through four signal methods plus regression models to flag independent links and time to onset.
Altogether 15,986 drug-related reports qualified, peaking in middle-aged and older adults with slightly more men. Immune suppressants, methotrexate, rituximab, tacrolimus, and amiodarone led report counts, and 22 drugs held significant links after adjustment. Median onset was 30 days, with about 75% of cases inside 150 days.
Catalog record
| CREATOR | Yunhan Zhao, Feiyang Zhao, Haoxiang Hu, Jianghai He, Yiting Ni, Pingping Jin, Xiao Wang, Zheru Jin, Yiren Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43157 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |