Adipose Tissue Plasticity and Adipogenesis: From Cellular Mechanisms to Therapeutic Targets in Obesity
Sílvia Rocha, Carina Proença, Félix Carvalho, Eduarda Fernandes · 2026
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Description
Sílvia Rocha and coauthors review fat tissue growth and remodeling in a 2026 article on obesity targets. Making new fat cells, called adipogenesis, follows gene cascades led by PPAR gamma and C/EBP proteins, tuned by Wnt, bone morphogenetic protein, and insulin signals. Healthy expansion stores fat safely and renews tissue.
In obesity, excess nutrients and hormone shifts stall healthy cell creation. Existing cells swell instead, oxygen drops, inflammation lingers, and fat spills into organs, driving insulin resistance and heart-metabolic disease. Guiding growth toward fresh, well-behaved fat cells rather than swollen ones is framed as a promising route to restore balance.
Catalog record
| CREATOR | Sílvia Rocha, Carina Proença, Félix Carvalho, Eduarda Fernandes |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86561 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |