Functional loss of PKMζ in the dorsal hippocampus potentiates the time-dependent increase in false contextual fear memory and impairs spatial recognition memory in mice
Haruna Takahashi, Yuna Kanemoto, Fuka Ohnuma, Yumi Tsuneura, Tohru Matsuki, Kenjiro Seki · 2026
Read Functional loss of PKMζ in the dorsal hippocampus potentiates the time-dependent increase in false contextual fear memory and impairs spatial recognition memory in mice by Haruna Takahashi, Yuna Kanemoto, Fuka Ohnuma, Yumi Tsuneura, Tohru Matsuki, Kenjiro Seki (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13294305.txt.
Description
Haruna Takahashi and colleagues probe false fear memories in mice for a 2026 brain study. Over time, context memories blur, and animals freeze in safe places that merely resemble a shock setting. The memory-keeping enzyme PKMζ was lowered or boosted in upper or lower hippocampus with viral tools two weeks before testing in young adult male mice.
False freezing appeared by 3 hours and grew by 24 hours. Lowering the enzyme in the upper hippocampus sharply boosted false freezing at 24 hours, while adding active enzyme blocked the rise and an inactive version mimicked loss. Upper hippocampus loss also hurt spatial recognition. Enzyme upkeep guards memory precision.
Catalog record
| CREATOR | Haruna Takahashi, Yuna Kanemoto, Fuka Ohnuma, Yumi Tsuneura, Tohru Matsuki, Kenjiro Seki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64874 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |