Resistance mechanisms and overcoming strategies for CAR T-cell therapy in B-cell hematologic malignancies
Pupu Li, Xia Xue, Zisen Zhang · 2026
Read Resistance mechanisms and overcoming strategies for CAR T-cell therapy in B-cell hematologic malignancies by Pupu Li, Xia Xue, Zisen Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13294257.txt.
Description
Pupu Li, Xia Xue, and Zisen Zhang review why CAR T therapy loses ground in B-cell blood cancers for 2026. The treatment reshaped care for relapsed lymphoma and leukemia, yet early and late resistance still cap lasting success. Causes sort into three buckets: traits inside the tumor, fading function of the engineered cells, and a suppressive tumor neighborhood.
Countermeasures are advancing on all three fronts, from multi-target receptors to metabolic and epigenetic tuning and neighborhood remodeling. The review maps each failure route to its matching fix and looks ahead to designs that hold activity longer. Better durability, not just stronger first hits, is the goal.
Catalog record
| CREATOR | Pupu Li, Xia Xue, Zisen Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38551 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |