Bioenergetic failure in diabetic peripheral neuropathy: from glucotoxicity to multidimensional metabolic imbalance
Wang Tao, Yunfeng Yu, Xuerong Wu, Jiacheng He, Xiu Liu, Juan Huang, Fan Xiao, Rong Yu · 2026
Read Bioenergetic failure in diabetic peripheral neuropathy: from glucotoxicity to multidimensional metabolic imbalance by Wang Tao, Yunfeng Yu, Xuerong Wu, Jiacheng He, Xiu Liu, Juan Huang, Fan Xiao, Rong Yu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13294226.txt.
Description
Wang Tao and colleagues frame diabetic nerve damage as an energy failure in a 2026 review. Long nerve fibers in the common stocking-glove pattern need heavy energy supply, and high blood sugar alone no longer explains their decay. Glucose, fat, and amino acid handling all go off balance, starving both neurons and their Schwann support cells.
Anatomy, energy pathways, and fiber-support teamwork are integrated into one account of how supply and demand drift apart. Fixing a single pathway is unlikely to stop or reverse damage, the authors argue. Restoring overall energy balance in both cell types offers the stronger path to preserving nerve function.
Catalog record
| CREATOR | Wang Tao, Yunfeng Yu, Xuerong Wu, Jiacheng He, Xiu Liu, Juan Huang, Fan Xiao, Rong Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89694 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |