Metabolically engineered probiotic OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy
Jie Lei, Bide Tong, Shihao Zhang, Zixuan Ou, Dingchao Zhu, Xingyu Zhou, Huaizhen Liang, Zhengdong Zhang, Lei Tan, Cao Yang, Xiaobo Feng · 2026
Read Metabolically engineered probiotic OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy by Jie Lei, Bide Tong, Shihao Zhang, Zixuan Ou, Dingchao Zhu, Xingyu Zhou, Huaizhen Liang, Zhengdong Zhang, Lei Tan, Cao Yang, Xiaobo Feng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13293997.txt.
Description
Jie Lei and co-authors engineer a vaccine-like treatment for stubborn bone infections, in a 2026 study. Chronic infection with drug-resistant Staphylococcus aureus creates a suppressed immune pocket where bacteria persist and bone cannot heal. Ideal therapy would first rally antibacterial immunity and later calm inflammation so repair can proceed. The team screened vesicles shed by a probiotic bacterium for exactly that two-stage behavior.
The vesicles carried a rich supply of a metabolic molecule called NAD+, and tuning the culture conditions boosted that cargo further. Early on, the engineered vesicles woke up dendritic cells and built strong antibody protection, clearing nearly all bacteria in animal challenges, including repeat attacks. Later, delivered NAD+ reprogrammed inflammatory macrophages at the defect site, and bone repair ran about ten times faster. The design treats infection and healing as one sequence.
Catalog record
| CREATOR | Jie Lei, Bide Tong, Shihao Zhang, Zixuan Ou, Dingchao Zhu, Xingyu Zhou, Huaizhen Liang, Zhengdong Zhang, Lei Tan, Cao Yang, Xiaobo Feng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |