Case Report: First occurrence of smoldering multiple myeloma in activated phosphoinositide 3-Kinase δ syndrome
Yanqiu Li, Linlin Huang, Wenhua He, Xin Wang, Ningning Tang, Dongmei Zhu, Xingli Jia, Chao Ding · 2026
Read Case Report: First occurrence of smoldering multiple myeloma in activated phosphoinositide 3-Kinase δ syndrome by Yanqiu Li, Linlin Huang, Wenhua He, Xin Wang, Ningning Tang, Dongmei Zhu, Xingli Jia, Chao Ding (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13293917.txt.
Description
Yanqiu Li and colleagues report a 2026 case described as the first pairing of smoldering multiple myeloma with activated PI3K delta syndrome, a rare inherited immune disorder. The young patient had repeated lung infections, swollen lymph tissue, genital herpes, autoimmunity, and raised IgM and IgG. Gene sequencing found a heterozygous PIK3CD change, also confirmed in the patient's son.
Bone marrow sampling and serum immunofixation showed monoclonal plasma cell growth, supporting the myeloma precursor diagnosis. No targeted therapy was given. The authors urge early genetic testing when the immune syndrome is suspected, since prompt recognition can improve outlook and family screening.
Catalog record
| CREATOR | Yanqiu Li, Linlin Huang, Wenhua He, Xin Wang, Ningning Tang, Dongmei Zhu, Xingli Jia, Chao Ding |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22210 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |