A brain reward circuit inhibited by next-generation weight-loss drugs in mice
Elizabeth N. Godschall, Taha Bugra Gungul, Isabelle R. Sajonia, Aleyna K. Buyukaksakal, Orien Li, Sophia Ogilvie, Austin B. Keeler, Guilian Tian, Yu Shi, Omar Koita, Chloe Xinzhu Guo, Tyler C. J. Deutsch, Eric J. Steacy, Maisie Crook, YuChen Zhang, Nicholas J. Conley, Gulsun Memi, Addison N. Webster · 2026
Read A brain reward circuit inhibited by next-generation weight-loss drugs in mice by Elizabeth N. Godschall, Taha Bugra Gungul, Isabelle R. Sajonia, Aleyna K. Buyukaksakal, Orien Li, Sophia Ogilvie, Austin B. Keeler, Guilian Tian, Yu Shi, Omar Koita, Chloe Xinzhu Guo, Tyler C. J. Deutsch, Eric J. Steacy, Maisie Crook, YuChen Zhang, Nicholas J. Conley, Gulsun Memi, Addison N. Webster (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13293854.txt.
Description
Elizabeth Godschall and co-authors trace a brain reward circuit that weight-loss drugs quiet in mice. Their 2026 study works with GLP-1 receptor drugs, which cut body weight and improve metabolic health. New small-molecule versions can be taken by mouth, but their binding favors human receptors, which has limited animal study.
The team built mice with a humanized version of the receptor to close that gap. The drugs acted on two tracks: classic hunger centers that guard body needs, and a reward circuit tied to tasty food. A group of neurons in the central amygdala lowered dopamine release in a reward hub, curbing pleasure-driven eating. Waking those neurons alone cut hedonic feeding in the mice.
Catalog record
| CREATOR | Elizabeth N. Godschall, Taha Bugra Gungul, Isabelle R. Sajonia, Aleyna K. Buyukaksakal, Orien Li, Sophia Ogilvie, Austin B. Keeler, Guilian Tian, Yu Shi, Omar Koita, Chloe Xinzhu Guo, Tyler C. J. Deutsch, Eric J. Steacy, Maisie Crook, YuChen Zhang, Nicholas J. Conley, Gulsun Memi, Addison N. Webster |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |