CHCHD3(MIC19): mitochondrial cristae structure regulation and disease associations
Zheng Tai Kuai, Xiao Min Zheng, Yue Yue Li, Tian Qi Wang · 2026
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Description
A 2026 review by Zheng Tai Kuai and colleagues centers on CHCHD3, also called MIC19, a core part of the MICOS system that shapes folds inside mitochondria. Those folds, called cristae, support energy production. The authors pull together what is known about the protein structure, its chemical modifications, and its links to cell metabolism and death.
Both too little and too much CHCHD3 can disturb balance, a pattern the authors call a Goldilocks effect. Faulty function is tied to brain disorders, heart disease, metabolic problems, and cancers. The review weighs early drug ideas, notes their limits, and flags open questions that block clinical use.
Catalog record
| CREATOR | Zheng Tai Kuai, Xiao Min Zheng, Yue Yue Li, Tian Qi Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64969 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |