Harnessing inter-spheroid spacing and structural connectivity to direct collective cell migration and host vessel integration in 3D engineered tissue
Sangmin Lee, SeongHeon Bae, Hyunseok Kwon, Ji Min Seok, Su A Park, Heungsoo Shin · 2026
Read Harnessing inter-spheroid spacing and structural connectivity to direct collective cell migration and host vessel integration in 3D engineered tissue by Sangmin Lee, SeongHeon Bae, Hyunseok Kwon, Ji Min Seok, Su A Park, Heungsoo Shin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13293761.txt.
Description
Sangmin Lee and co-authors engineer, in a 2026 study, tissue scaffolds that use ball-shaped cell clusters to grow blood vessel networks. Getting vessels into thick lab-grown tissue is a core hurdle for regenerative medicine, since cells deep inside starve without flow.
Clusters of vessel and fat stem cells sat in gel inside printed frames with set spacing and linked pores. Clustered cells sprouted and migrated together better than loose cells, with higher vessel and matrix gene activity. Spacing between clusters tuned how networks formed, and more linked pores let host vessels grow in better in animals. Host vessels lined up along frame strands, guiding design.
Catalog record
| CREATOR | Sangmin Lee, SeongHeon Bae, Hyunseok Kwon, Ji Min Seok, Su A Park, Heungsoo Shin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77176 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |