Orchestrating the bone microenvironment to enhance bone-vascular coupling in critical-sized bone defect self-repairing: Advances and prospects
Zhiheng Xia, Mingming Zhao, Jiadong Lu, Jinyu Wang, Rongquan Duan · 2026
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Description
Zhiheng Xia and co-authors review, in a 2026 paper, how steering the bone healing environment can help large bone defects repair themselves by coupling bone and blood vessel growth. Big defects fail to heal alone, and the local setting decides whether repair stalls or proceeds.
Early healing is dominated by bone removal, with inflammation, low oxygen, and acid clearing dead tissue. Later, immune cells shift to a repair mode, acidity fades, and signals boost vessel growth and new bone laying. Stress factors such as oxygen lack and oxidation shape both phases. Targeting those shared stresses may break harmful loops and switch on self-repair.
Catalog record
| CREATOR | Zhiheng Xia, Mingming Zhao, Jiadong Lu, Jinyu Wang, Rongquan Duan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82156 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |