Serum SOS1 as a prognostic biomarker and therapeutic target for progressive liver disease
Peter U Amadi, Govind S Gill, Chiamaka W Amadi, Justice O Osuoha, Prince C Odika, Raj M Patel, Suha J Jarad, Hong-mei Gu, Moattar Latif, Joy A Amadi, Celestine N Ekweogu, Melford U Elendu, Emmanuel N Agomuo, Alastair O’Brien, Barbora de Courten, Ralf Weiskirchen, Da-wei Zhang · 2026
Read Serum SOS1 as a prognostic biomarker and therapeutic target for progressive liver disease by Peter U Amadi, Govind S Gill, Chiamaka W Amadi, Justice O Osuoha, Prince C Odika, Raj M Patel, Suha J Jarad, Hong-mei Gu, Moattar Latif, Joy A Amadi, Celestine N Ekweogu, Melford U Elendu, Emmanuel N Agomuo, Alastair O’Brien, Barbora de Courten, Ralf Weiskirchen, Da-wei Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13293661.txt.
Description
Peter U Amadi and a large team test, in a 2026 study, whether blood levels of a protein called SOS1 can forecast worsening chronic liver disease. No dependable blood marker yet tracks the march from scarring to liver cancer in a single patient.
A cohort of 556 people across disease stages was followed for up to 36 months with repeated SOS1 measures. Levels rose step by step with stage and tracked standard scarring scores closely. Higher starting levels predicted death and beat two standard markers at sorting risk. Blocking SOS1 in scarring cells and a mouse model reduced scarring genes and tissue scarring, linking marker to mechanism.
Catalog record
| CREATOR | Peter U Amadi, Govind S Gill, Chiamaka W Amadi, Justice O Osuoha, Prince C Odika, Raj M Patel, Suha J Jarad, Hong-mei Gu, Moattar Latif, Joy A Amadi, Celestine N Ekweogu, Melford U Elendu, Emmanuel N Agomuo, Alastair O’Brien, Barbora de Courten, Ralf Weiskirchen, Da-wei Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71636 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |