Role of (pro) renin receptor in adriamycin-induced cardiomyopathy
Hui Ma, Liqin Wang, Chenggang Mao, Yang Hu, Xingqing Guo, Lei Li, Fang Wang, Renzheng Guan, Longbo Zheng · 2026
Read Role of (pro) renin receptor in adriamycin-induced cardiomyopathy by Hui Ma, Liqin Wang, Chenggang Mao, Yang Hu, Xingqing Guo, Lei Li, Fang Wang, Renzheng Guan, Longbo Zheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13293660.txt.
Description
Hui Ma and co-authors study, in a 2026 paper, the role of the (pro)renin receptor in heart damage caused by the cancer drug adriamycin. The receptor belongs to a hormone system tied to heart disease, yet its part in this drug injury was not settled.
Receptor levels rose in sick rat hearts and in drug-treated heart cells. Forcing higher levels worsened heart function and thickening, while a blocker drug called PRO20 eased the injury in live rats. Lowering the receptor cut scarring, inflammation, cell death, and oxidative stress in rats and cells. Blocking a downstream signal gave like gains, marking the receptor as a drug target.
Catalog record
| CREATOR | Hui Ma, Liqin Wang, Chenggang Mao, Yang Hu, Xingqing Guo, Lei Li, Fang Wang, Renzheng Guan, Longbo Zheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56790 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |