Nonnutritive Sweeteners and Cardiovascular Risk
Karl Nadolsky · 2026
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Description
Karl Nadolsky writes a 2026 letter disputing a review that filed nonnutritive sweeteners under evidence of harm for heart health. The review leaned on large cohort studies tying artificially sweetened drinks to higher disease rates. Nadolsky argues those observational links are poisoned by reverse causation: people switch to diet drinks because they are already sick or gaining weight, which manufactures the association.
Against that, he marshals randomized trial evidence. Intervention studies repeatedly show sweetened-without-sugar drinks beating sugary ones, sometimes matching or beating water, and meal replacements using these sweeteners aiding weight loss and diabetes remission. A cited meta-analysis of trials by Qin and colleagues anchors the safety case. His plea: let controlled evidence, not confounded correlations, steer what clinicians tell patients about sweeteners.
Catalog record
| CREATOR | Karl Nadolsky |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 5160 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |