Histomorphometric Evaluation of Socket Preservation Healing Using Xenogeneic Bone Substitute Combined with Statin: A Prospective Split-Mouth Clinical Pilot Study
Tomislav Katanec, Luka Šimunović, Robert Likić, Igor Smojver, Stjepanka Lešić, Ivica Pelivan, Dragana Gabrić · 2026
Read Histomorphometric Evaluation of Socket Preservation Healing Using Xenogeneic Bone Substitute Combined with Statin: A Prospective Split-Mouth Clinical Pilot Study by Tomislav Katanec, Luka Šimunović, Robert Likić, Igor Smojver, Stjepanka Lešić, Ivica Pelivan, Dragana Gabrić (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13292657.txt.
Description
Tomislav Katanec and colleagues test a 2026 dental pilot idea: adding the cholesterol drug simvastatin to a bovine bone graft might help extraction sockets heal with more new bone. Nine patients needing teeth out on both sides received the graft alone in one socket and graft plus locally applied simvastatin, 1 milligram in saline, in the other. Core biopsies at three months were measured under the microscope.
Tissue makeup barely differed between sides. Connective tissue dominated both, at 59.1 percent in control sockets and 64.3 percent in statin sockets on average. New bone made up 31.0 percent against 26.2 percent, and leftover graft about 10 percent either way, all statistically insignificant. The authors conclude that at this dose and delivery, simvastatin adds nothing to early socket preservation.
Catalog record
| CREATOR | Tomislav Katanec, Luka Šimunović, Robert Likić, Igor Smojver, Stjepanka Lešić, Ivica Pelivan, Dragana Gabrić |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29156 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |