LATS kinase activity and tumor suppressor function are regulated by a second autophosphorylation site
Ruxin Jin, Zhenxing Zhong, Rui Zhu, Anlan Zhang, Jian Li, Fa-Xing Yu, Yu Wang · 2026
Read LATS kinase activity and tumor suppressor function are regulated by a second autophosphorylation site by Ruxin Jin, Zhenxing Zhong, Rui Zhu, Anlan Zhang, Jian Li, Fa-Xing Yu, Yu Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13292594.txt.
Description
Ruxin Jin and co-authors report a 2026 study on how a pair of enzymes that curb cell growth switch on. The pair sits at the core of a path that controls how cells grow, split, and stay alive. Past work showed that other enzymes prime the pair, which then adds a tag to itself to fully wake up.
The team found a second self-tag site on each enzyme, set in a short pattern shared across species. Tagging at that site is needed for full strength, since a change that blocks it weakens the pair a lot. With the pair weak, a growth driver down the path works more freely. The find adds a new step to how this growth path is tuned.
Catalog record
| CREATOR | Ruxin Jin, Zhenxing Zhong, Rui Zhu, Anlan Zhang, Jian Li, Fa-Xing Yu, Yu Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |