Heat stress promotes ferroptosis in Jiaji duck myocardium by disrupting iron homeostasis and inducing lipid peroxidation
Qijun Liang, Xinli Zheng, Tieshan Xu, Piaoran Liu, Yiyong Chen, Zhemin Lin, Lihong Gu · 2026
Read Heat stress promotes ferroptosis in Jiaji duck myocardium by disrupting iron homeostasis and inducing lipid peroxidation by Qijun Liang, Xinli Zheng, Tieshan Xu, Piaoran Liu, Yiyong Chen, Zhemin Lin, Lihong Gu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13292588.txt.
Description
Qijun Liang and co-authors show heat stress killing duck heart cells through an iron-driven route, in a 2026 study. Jiaji ducks endured three hours of severe heat and humidity, while heart cells faced heat in dishes. Survival fell as exposure lengthened, and blood markers of heart damage climbed. Heart fibers looked disorganized under the microscope, and mitochondria shrank with lost inner folds. Protein profiling found over a thousand changed proteins.
Ferroptosis, a death program fueled by iron and fat oxidation, stood out in the changed pathways. Tissues held more reactive oxygen, more fat damage products, and more ferrous iron, while the protective glutathione system ran dry. Key proteins shifted in the directions ferroptosis predicts, and an energy-sensing pathway switched on alongside. Dish-grown cells mirrored the pattern, proving a direct cell response. The authors name targets for shielding poultry hearts during heat waves.
Catalog record
| CREATOR | Qijun Liang, Xinli Zheng, Tieshan Xu, Piaoran Liu, Yiyong Chen, Zhemin Lin, Lihong Gu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |