Dementia risk by metabolic health and obesity in two prospective cohorts
Martin Nakash, Elsa Ojalehto Lindfors, Yiqiang Zhan, Anna K. Dahl Aslan, Chandra A. Reynolds, Peggy Ler, Ida K. Karlsson · 2026
Read Dementia risk by metabolic health and obesity in two prospective cohorts by Martin Nakash, Elsa Ojalehto Lindfors, Yiqiang Zhan, Anna K. Dahl Aslan, Chandra A. Reynolds, Peggy Ler, Ida K. Karlsson (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13292518.txt.
Description
Martin Nakash and co-authors ask a 2026 dementia question across two big aging cohorts: is it obesity or metabolic ill-health that carries the risk? Midlife obesity is a known dementia factor, but late-life obesity sometimes looks harmless. The team sorted 11,482 Americans and 13,068 Swedes by weight and by metabolic health, defined through blood sugar, blood pressure, and lipids.
Metabolic unhealthiness, with or without obesity, pointed toward higher dementia risk in both midlife and late life. The clearest signals were metabolically unhealthy non-obese women in midlife in the US cohort and late-life men in the Swedish one. Obesity with metabolic health showed no significant risk and even trended protective. The authors argue metabolic health, especially in midlife, deserves the attention usually lavished on weight alone.
Catalog record
| CREATOR | Martin Nakash, Elsa Ojalehto Lindfors, Yiqiang Zhan, Anna K. Dahl Aslan, Chandra A. Reynolds, Peggy Ler, Ida K. Karlsson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64785 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |