Conjunctival goblet and epithelial cell changes in antidepressant-associated dry eye disease: a case–control study
Rekha Chotaliya, Neeta Mishra, Neelam Prasad, Archana Buch, Parisha Kelkar, Veshal Madan · 2026
Read Conjunctival goblet and epithelial cell changes in antidepressant-associated dry eye disease: a case–control study by Rekha Chotaliya, Neeta Mishra, Neelam Prasad, Archana Buch, Parisha Kelkar, Veshal Madan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13292508.txt.
Description
Rekha Chotaliya and colleagues compare a 2026 case-control look at the eye surface of people taking antidepressants, drugs known to unsettle the tear film. Seventy-two users and seventy matched controls aged 20 to 40 underwent tear breakup and Schirmer tests, symptom scoring, surface staining, and impression cytology that counts mucus-making goblet cells. The drug mix spanned SSRI, SNRI, and tricyclic types.
Users had roughly half the goblet cell density of controls, 183 against 366 cells per square millimeter in the readings, plus weaker tear stability and wetting. Symptom scores more than doubled, and corneal staining odds ran thirteen times higher. Goblet cell counts tracked with both tear breakup time and Schirmer results. No drug class stood out as worse. The authors advise routine eye monitoring for patients on antidepressants.
Catalog record
| CREATOR | Rekha Chotaliya, Neeta Mishra, Neelam Prasad, Archana Buch, Parisha Kelkar, Veshal Madan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33874 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |