Nrf2 deficiency converts the ESCC microenvironment into an immunologically active state via the GPX2-ICD-DC signaling path
Yu Liu, Qing Guo, Ming Liu, Dashan Ai, Yun Chen, Qi Liu, Shengnan Hao, Chong Li, Fengtao Su, Kuaile Zhao · 2026
Read Nrf2 deficiency converts the ESCC microenvironment into an immunologically active state via the GPX2-ICD-DC signaling path by Yu Liu, Qing Guo, Ming Liu, Dashan Ai, Yun Chen, Qi Liu, Shengnan Hao, Chong Li, Fengtao Su, Kuaile Zhao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13292439.txt.
Description
Yu Liu and co-authors uncover a 2026 immune side to Nrf2, the antioxidant master switch, in esophageal squamous cell carcinoma. Radiation resistance plagues this cancer, and the team asked whether Nrf2 also dulls the immune alarm that dying tumor cells should raise. They built mice whose esophageal tumors lack Nrf2, profiled the immune landscape by single-cell sequencing, and ran co-culture tests with dendritic and T cells.
Without Nrf2, tumors lost the antioxidant enzyme GPX2 and grew easier to kill with radiation, spilling classic immunogenic death signals such as ATP, HMGB1, and surface calreticulin. Dendritic cells responded by releasing IP-10, which proved essential for recruiting and firing up CD8 T cells. Living-animal tests confirmed stronger radiation response and deeper T cell infiltration. The authors pitch the Nrf2-GPX2 axis as a way to heat up cold tumors.
Catalog record
| CREATOR | Yu Liu, Qing Guo, Ming Liu, Dashan Ai, Yun Chen, Qi Liu, Shengnan Hao, Chong Li, Fengtao Su, Kuaile Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59579 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |