Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology
Michael Candlish, Jan Hofmann, Desirée Brösamle, Annika Haessler, Murphy DeMeglio, Angelos Skodras, Georgi Tushev, Eloah S De Biasi, Stefan Günther, René Wiegandt, Heidi Theis, Elena De Domenico, Nina Sofia Hermann, Peter Breunig, Christina Sauerland, K Peter R Nilsson, Marc D Beyer, Mario Looso, Ma · 2026
Read Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology by Michael Candlish, Jan Hofmann, Desirée Brösamle, Annika Haessler, Murphy DeMeglio, Angelos Skodras, Georgi Tushev, Eloah S De Biasi, Stefan Günther, René Wiegandt, Heidi Theis, Elena De Domenico, Nina Sofia Hermann, Peter Breunig, Christina Sauerland, K Peter R Nilsson, Marc D Beyer, Mario Looso, Ma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13292430.txt.
Description
Michael Candlish, Jan Hofmann, and colleagues report that a stroke-like injury can push brain immune cells toward protection, in a 2026 study. Most Alzheimer's patients also carry blood vessel damage, yet combined effects on microglia were unclear. The team modeled amyloid pathology together with ischemic injury. Microglia answered by switching into an unexpected state rich in the protein ApoE. Their fat handling improved markedly.
These reprogrammed cells packed amyloid into tight, compact plaques that seem relatively harmless. The plaques resembled those found in people who stay sharp despite heavy amyloid. The findings break the idea that microglia slide only toward dysfunction beside amyloid. A second insult, timed right, reopened a helpful program instead. Pathways around ApoE, complement, and lysosomal cleanup stand out as drug targets. The authors propose steering microglia toward this protective state as a treatment strategy. Human relevance still needs testing.
Catalog record
| CREATOR | Michael Candlish, Jan Hofmann, Desirée Brösamle, Annika Haessler, Murphy DeMeglio, Angelos Skodras, Georgi Tushev, Eloah S De Biasi, Stefan Günther, René Wiegandt, Heidi Theis, Elena De Domenico, Nina Sofia Hermann, Peter Breunig, Christina Sauerland, K Peter R Nilsson, Marc D Beyer, Mario Looso, Ma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |