Dandelion exosome-like nanovesicles alleviate sepsis-induced acute kidney injury via SLC7A11-regulated ferroptosis
Pan Zhang, Fanfan Cao, Limin Xu, Xinghui Liu · 2026
Read Dandelion exosome-like nanovesicles alleviate sepsis-induced acute kidney injury via SLC7A11-regulated ferroptosis by Pan Zhang, Fanfan Cao, Limin Xu, Xinghui Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13292357.txt.
Description
Pan Zhang's team tests a 2026 plant remedy for sepsis-driven kidney injury: exosome-like nanovesicles squeezed from dandelion. Sepsis often wrecks the kidneys, and the iron-driven cell death called ferroptosis seems to help drive that damage. The team isolated the vesicles, named PGY-Exo, and tried them in a living sepsis kidney model plus human vein cells inflamed with bacterial toxin.
Labeled vesicles entered both the cultured cells and kidney tissue. Treatment calmed reactive oxygen buildup and lowered TNF-alpha, IL-1beta, and IL-6 levels in their experiments. Proteomics fingered the transporter SLC7A11 as the key downstream target. Knocking that protein down erased the vesicles' protection, and the authors conclude the vesicles lift SLC7A11 to hold back ferroptosis and spare the kidney.
Catalog record
| CREATOR | Pan Zhang, Fanfan Cao, Limin Xu, Xinghui Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18749 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |