Identification of alpha1-oleate as a potent regulator of adipokine-dependent metabolism, in bladder cancer tissue
Farhan Haq, Siddharth Chinchankar, Ines Ambite, Shahram Ahmadi, Hien Tran, Atefeh Nazari, Antonin Brisuda, Jaromir Hacek, Marek Babjuk, Catharina Svanborg · 2026
Read Identification of alpha1-oleate as a potent regulator of adipokine-dependent metabolism, in bladder cancer tissue by Farhan Haq, Siddharth Chinchankar, Ines Ambite, Shahram Ahmadi, Hien Tran, Atefeh Nazari, Antonin Brisuda, Jaromir Hacek, Marek Babjuk, Catharina Svanborg (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13292342.txt.
Description
Farhan Haq and co-authors examine a 2026 twist in bladder cancer treatment: the tumor-killing complex alpha1-oleate also rewires tumor metabolism. Samples came from patients in a placebo-controlled trial of the drug instilled into the bladder. Cells shed into urine at each treatment and biopsies after six instillations went through RNA sequencing, and urine was screened on adipokine arrays.
Treated tissue switched off broad sets of metabolic genes compared with placebo. Networks for building glucose and lipids quieted, including the genes for adiponectin and leptin, two hormone-like regulators of fat and sugar. Leptin appeared to sit upstream of the adiponectin response, and the two networks intertwined strongly in treated tumors. Shed cells showed the metabolic shift happened fast, and urine levels of both proteins rose after treatment.
Catalog record
| CREATOR | Farhan Haq, Siddharth Chinchankar, Ines Ambite, Shahram Ahmadi, Hien Tran, Atefeh Nazari, Antonin Brisuda, Jaromir Hacek, Marek Babjuk, Catharina Svanborg |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44176 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |