Retrospective evaluation of Selexipag monotherapy on pulmonary hemodynamics in newly diagnosed, treatment-naïve patients with chronic thromboembolic pulmonary hypertension prior to balloon pulmonary angioplasty
Naohiro Komura, Teruyasu Sugano, Toru Suzuki, Fumiaki Ono, Maria Abe, Uno Yamamoto, Keisuke Sekiya, Sho Kodama, Shintaro Minegishi, Shingo Kato, Kozo Okada, Junya Hosoda, Masaaki Konishi, Fumiyuki Otsuka, Noriaki Iwahashi, Tomoaki Ishigami, Daisuke Utsunomiya, Makoto Mo, Kiyoshi Hibi · 2026
Read Retrospective evaluation of Selexipag monotherapy on pulmonary hemodynamics in newly diagnosed, treatment-naïve patients with chronic thromboembolic pulmonary hypertension prior to balloon pulmonary angioplasty by Naohiro Komura, Teruyasu Sugano, Toru Suzuki, Fumiaki Ono, Maria Abe, Uno Yamamoto, Keisuke Sekiya, Sho Kodama, Shintaro Minegishi, Shingo Kato, Kozo Okada, Junya Hosoda, Masaaki Konishi, Fumiyuki Otsuka, Noriaki Iwahashi, Tomoaki Ishigami, Daisuke Utsunomiya, Makoto Mo, Kiyoshi Hibi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13292260.txt.
Description
Naohiro Komura and a large team review a 2026 retrospective question: what does selexipag alone do to lung pressures in fresh, untreated chronic thromboembolic pulmonary hypertension? The drug gained Japanese approval for this clot-based lung condition in 2021, yet its solo effect before balloon angioplasty was unclear. Charts from Yokohama City University Hospital covered patients treated between 2021 and 2024.
Thirty patients entered the analysis, fifteen on selexipag and fifteen on riociguat, all heading to a first balloon procedure. Selexipag cut mean pulmonary artery pressure from 39.0 to 33.6 mmHg on average and lowered vascular resistance as well. Riociguat matched those drops and additionally raised cardiac output. The authors call the work exploratory and ask for prospective trials to confirm the pattern.
Catalog record
| CREATOR | Naohiro Komura, Teruyasu Sugano, Toru Suzuki, Fumiaki Ono, Maria Abe, Uno Yamamoto, Keisuke Sekiya, Sho Kodama, Shintaro Minegishi, Shingo Kato, Kozo Okada, Junya Hosoda, Masaaki Konishi, Fumiyuki Otsuka, Noriaki Iwahashi, Tomoaki Ishigami, Daisuke Utsunomiya, Makoto Mo, Kiyoshi Hibi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46084 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |