Circ_0008777 promotes head and neck squamous cell carcinoma progression by elevating c-Myc expression levels via interacting with PC4 and miR-185–3p
Weixing Liu, Zhiyuan Wang, Pei Li, Yue Liu, Jia Chen, Zhi Shi, Hui Liu, Jin Ye · 2026
Read Circ_0008777 promotes head and neck squamous cell carcinoma progression by elevating c-Myc expression levels via interacting with PC4 and miR-185–3p by Weixing Liu, Zhiyuan Wang, Pei Li, Yue Liu, Jia Chen, Zhi Shi, Hui Liu, Jin Ye (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13292258.txt.
Description
Weixing Liu and co-authors trace a 2026 mechanism by which a circular RNA drives head and neck squamous cell carcinoma. The molecule, circ_0008777, runs high in these tumors and matches poorer patient outcomes. Most cases of this cancer, arising in the mouth, throat, and voice box, are caught late, so fresh targets matter.
Experiments in cells and animals show the circular RNA lifting levels of c-Myc, a powerful growth driver, through two routes at once. It binds the protein PC4 to boost c-Myc gene transcription directly. It also soaks up miR-185-3p, a small RNA that normally restrains c-Myc. With both brakes off, tumors grew and spread more readily. The authors propose blocking circ_0008777 as a possible treatment strategy for this cancer.
Catalog record
| CREATOR | Weixing Liu, Zhiyuan Wang, Pei Li, Yue Liu, Jia Chen, Zhi Shi, Hui Liu, Jin Ye |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35811 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |